Oligoclonal band analysis (OCB) is the standard for detecting intrathecal immunoglobulin synthesis in CSF to support MS diagnosis.
Free light chains are a new alternative biomarker to detect intrathecal immunoglobulin synthesis in CSF, helping to support an MS diagnosis. Compared to oligoclonal band (OCB) analysis, Free light chains analysis using Freelite offers:
As discussed in a recent publication by Professor Ferraro and colleagues:
“FLC were also detected in the CSF of the small proportion of patients diagnosed with MS without OCB and in CIS patients, suggesting they may be a more sensitive marker of the disease”
“Kappa index values ≥ 5.8 were present at onset in 25% of 92 OCB-negative patients with suspected/possible MS who subsequently received a diagnosis of MS”